Eryacne

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Erythromycin belongs to the family of medicines called antibiotics. Erythromycin topical preparations are used on the skin to help control acne. They may be used alone or with one or more other medicines that are applied to the skin or taken by mouth for acne. They may also be used for other problems, such as skin infections, as determined by your doctor.

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Erythromycin has in vitro activity against a number of aerobic and anaerobic Gram-positive bacteria as well as some Gram-negative bacilli. Erythromycin inhibits protein synthesis in susceptible bacteria by reversibly binding to the 50S ribosomal subunits.
Following topical application to the skin, erythromycin significantly inhibits the growth of Propionibacterium acnes on the surface of the skin and reduces the concentration of free fatty acids in the sebum.
In vitro and animal studies show that erythromycin has anti-inflammatory properties.
In clinical use of topical erythromycin strains of Propionibacterium acnes resistant to erythromycin were reported in about 20% of subjects. The resistant organisms recovered were also resistant to clindamycin.

Pharmacokinetics
Percutaneous absorption studies in animals show very low absorption of erythromycin. In one clinical study, the penetration of topical erythromycin to lower skin layers suggested that systemic absorption may be low but no definitive bioavailability study has been conducted with ERYACNE. It is not known whether erythromycin is absorbed from denuded skin, wounds or mucous membranes.

Indications
Eryacne is indicated for the treatment of mild to moderate acne vulgaris.

Dosage and Administration
Wash the affected area with a mild non-alkaline soap. Rinse thoroughly and pat dry. A thin film of ERYACNE should be applied to the cleansed, affected areas twice daily. Allow to dry for a couple of minutes to prevent the gel from being wiped off. Replace the cap tightly after use.
As a rule, an 8 week treatment period will be necessary, but in instances of recurrence, the period of treatment may be prolonged further.

Contraindications
ERYACNE should not be used by patients who have shown hypersensitivity to erythromycin or any of the other ingredients. If a reaction suggesting sensitivity or severe irritation occurs, use of the medication should be discontinued. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, to discontinue temporarily or to discontinue use altogether.